Ana Martín-Villalba

Joint recording of past and present transcriptomes reconstructs single-cell trajectories

This paper introduces scReMeMber-Seq, a method to reconstruct single-cell trajectories by linking past and present transcriptomes using methylation-based memory recording.

Inflammatory injury drives CIN and STING loss in polyploidpancreatic acinar cells

The paper shows that inflammatory injury leads to polyploid pancreatic acinar cells with CIN and STING loss, contributing to tissue repair and cancer risk.

Unraveling Regulatory Feedback Mechanisms in Adult Neurogenesis Through Mathematical Modelling

This study uses mathematical models to analyze regulatory feedback mechanisms in adult neurogenesis, finding that neural stem cells predominantly regulate lineage dynamics.

Single-cell triple-omics uncovers DNA methylation as key feature of stemness in the healthy and ischemic adult brain

The paper uses single-cell triple-omics to show DNA methylation patterns are key to stemness in adult brain cells, especially under ischemic conditions.

Analyzing single-cell bisulfite sequencing data with MethSCAn

The paper introduces MethSCAn, a tool for analyzing scBS data that improves methylation quantification and DMR detection, enhancing cell type discrimination with fewer cells.

Interferon regulates stem cell function at all ages by orchestrating mTOR and cell cycle

This study shows interferon regulates stem cell function across all ages by controlling mTOR and cell cycle, with beneficial effects in youth and harmful effects in aging brains.

In vivo high-throughput screening of novel adeno-associated viral capsids targeting adult neural stem cells in the subventricular zone

The paper identifies AAV variants that efficiently target adult neural stem cells in the subventricular zone, enabling genetic modification for potential regenerative therapies.

Single cell 3'UTR analysis identifies changes in alternative polyadenylation throughout neuronal differentiation and in autism

The paper analyzes 3'UTR changes during neuronal differentiation and in ASD, finding longer 3UTRs in ASD patients and a role for CPEB4 and APLP1 in APA regulation.

Onset of differentiation is posttranscriptionally controlled in adult neural stem cells

The paper shows that posttranscriptional regulation, specifically translational repression, controls the onset of differentiation in adult neural stem cells.

An immune-CNS axis activates remote hippocampal stem cells following Spinal Transection Injury

This study shows that spinal transection injury activates distant hippocampal stem cells via an immune-CNS axis, leading to increased neuron production and improved memory performance.

Post-transcriptional regulation of adult CNS axonal regeneration by Cpeb1

This study identifies post-transcriptional regulation by Cpeb1 as a mechanism enhancing CNS axonal regeneration in mice and Drosophila.

Revealing Age-Related Changes of Adult Hippocampal Neurogenesis

This study uses a mathematical model and experimental data to show that aged hippocampal NSCs remain quiescent longer and have a higher reactivation probability, which can be rescued by increased Wnt activity.

RNA-seq library preparation from single pancreatic acinar cells

The paper develops a protocol for single-cell RNA sequencing of pancreatic acinar cells, which have high ribonuclease content, achieving high-quality libraries with 5x106 reads per cell and 80% transcript mapping rate.