Olivier Tassy

The paper investigates the dynamic behavior of RNA polymerase II and its initiation factors during transcription activation in live cells, revealing distinct kinetic behaviors and a quantitative model for PIC assembly.

The paper develops SpaceCycle to infer cell-cycle phases and oscillatory gene expression from spatial transcriptomic data, revealing spatial and temporal patterns of proliferation in tumors.

The paper uses single-cell multiomics to analyze mRNA metabolism and chromatin accessibility dynamics during the cell cycle, revealing oscillatory patterns and regulatory mechanisms.

This study develops an in vitro protocol to recapitulate early paraxial mesoderm development in mouse ES cells, showing efficient differentiation into muscle precursor cells and functional muscle fibers.