Jérome Chal

This study uses single-cell RNA sequencing to identify brown fat precursors and demonstrates their in vitro differentiation into functional brown adipocytes.

This study uses bulk and single-cell assays to analyze gene expression, histone modifications, and chromatin features in ESCs transitioning to mesoderm lineages, identifying cis-regulatory elements and transcription factors involved in lineage specification.

This study develops an in vitro protocol to recapitulate early paraxial mesoderm development in mouse ES cells, showing efficient differentiation into muscle precursor cells and functional muscle fibers.

The paper shows that Warburg-like metabolism in the posterior region of embryos coordinates FGF and Wnt signaling to promote embryonic axis elongation.