Author

Leah M. Ziolkowski

University of Chicago

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Kay F. MacleodiD· 2 shared Alexander MuiriD· 1 shared Alica K. MichelsiD· 1 shared Anika T. Thomas-TothiD· 1 shared Christopher J. HalbrookiD· 1 shared Christopher R. WeberiD· 1 shared Colin S. SheehaniD· 1 shared Darby AgovinoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Kay F. MacleodORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

DHHC7 palmitoylates KRAS4A and promotes mutant KRAS-driven pancreatic cancers

Wenzhe Chen, George E. Maio, Xiao Chen, Xuan Lü, Jiaqi Zhao, Neha Arora, Yinong Liu, Leah M. Ziolkowski, Kay F. Macleod, Yong Zhou, Hening Lin

This study identifies DHHC7 as a palmitoyl transferase that modifies KRAS4A, enhancing its membrane localization and activation, and shows that targeting DHHC7 inhibits pancreatic tumor growth.

bioRxiv · Apr 2, 2026 · PreprintCancer Biology

Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer

Colin S. Sheehan, Lyndon Hu, Guillaume Cognet, Grace Croley, Thao Trang Nguyen, Anika T. Thomas-Toth, Darby Agovino, Patrick B. Jonker, Mumina Sadullozoda, Leah M. Ziolkowski, James K. Martin, Alica K. Michels, Ranya Dano, Mohammed A. Khan, Rasangi Perera, , Alexander Muir

This study shows that pancreatic cancer cells in a nutrient-stressed tumor microenvironment develop drug tolerance, and identifies BCL-XL inhibition as a potential therapeutic strategy.

bioRxiv · Sep 4, 2025 · PreprintCancer Biology