Author

Shane S. Kelly

Pacific Northwest National LaboratoryORCID 0000-0002-6252-5895Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Pathology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Assay:proteomics· 2 Assay:CITE-seq· 1 Research Focus:database / resource· 1 Assay:imaging· 1

Frequent Co-Authors

Vladislav PetyukiD· 3 shared Clayton E. MathewsiD· 2 shared Elizabeth Ashley ButterworthiD· 2 shared Mark A. AtkinsoniD· 2 shared Martha Campbell‐ThompsoniD· 2 shared Rohit KulkarniiD· 2 shared Weijun QianiD· 2 shared A. C. SwenseniD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersSystems Biology

Vladislav PetyukORCID

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3 papers

Recent·Most cited

Systems BiologybioRxivPreprintNov 10, 2025

Single-Islet Proteomics Maps Pseudo-Temporal Islet Immune Responses and Dysfunction in Stage 1 Type 1 Diabetes

Shane S. Kelly, Soumyadeep Sarkar, Sarai M. Williams…·Weijun Qian

The paper uses single-islet proteomics to analyze pseudo-temporal immune responses and beta-cell dysfunction in stage 1 T1D, identifying key pathways involved in islet dysfunction.

1 citation

humanproteomics

𝕏 PostBluesky

PathologyDiabetologiaPeer-reviewedJun 2, 2025

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Increased Inflammation as well as Decreased Endoplasmic Reticulum Stress and Translation Differentiate Pancreatic Islets of Pre-symptomatic Stage 1 Type 1 Diabetes and Non-diabetic Cases

A. C. Swensen, Paul Piehowski, Jing Chen…·Weijun Qian

Laser-microdissected islets of 3 multiple-autoantibody-positive stage 1 type 1 diabetes donors versus matched controls show 202 altered proteins: immune and glycolytic up, translation and ER-stress proteins down.

9 citations

humanproteomics

𝕏 PostBluesky

NeurosciencebioRxivPreprintMar 31, 2025

A proteogenomic tool uncovers protein markers for human microglial states

Verena Claudia Haage, Alex R. Bautista, John F. Tuddenham…·Philip L. De Jager

The paper introduces a proteomic tool to identify protein markers for human microglial states and validates their utility in purification and differentiation.

2 citations

humanCITE-seq

𝕏 PostBluesky