Graziana Gatto

The spinal premotor network driving scratching flexor and extensor alternation

The paper investigates the dynamics of spinal CPG neurons in scratch reflex rhythmogenesis and develops a neuromechanical model to explain their interactions.

Endocytic adaptor AP-2 maintains Purkinje cell function by balancing cerebellar parallel and climbing fiber synapses

This study shows that AP-2 maintains Purkinje cell function by balancing synaptic inputs from parallel and climbing fibers, preventing degeneration and motor dysfunction.

Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity

This study shows that autophagy regulator ATG5 protects cerebellar Purkinje cells by maintaining glycolytic activity, preventing neurodegeneration through regulation of glucose transporter 2.

The transcriptomic landscape of spinal V1 interneurons reveals a role for En1 in specific elements of motor output

The paper presents a single-nucleus transcriptomic atlas of spinal V1 interneurons across development, identifying En1's role in specifying a subset of V1Pou6f2 interneurons and its impact on locomotor output.

AutoGaitA: A versatile quantitative framework for kinematic analyses across species, perturbations and behaviours

AutoGaitA provides a framework for analyzing motor programs across species and behaviors, showing age-related loss of propulsive strength and task-dependent adaptations in mice.

Myomatrix arrays for high-definition muscle recording

The paper introduces Myomatrix arrays, a high-resolution electrode technology for recording muscle activity from motor units across species during natural behaviors.

A spinal synergy of excitatory and inhibitory neurons coordinates ipsilateral body movements

The paper identifies a spinal microcircuit involving V2a and V2b neurons that coordinate ipsilateral body movements during locomotion, showing antagonistic and synergistic roles in motor control.