mRNA vaccination overcomes hemozoin-mediated impairment of whole parasite vaccine efficacy for malaria
Mariah Hassert, Lisa L. Drewry, Lecia L. Pewe, Lisa S. Hancox, Rui He, Sahaana A. Arumugam, Madison R. Mix, Aliasger K. Salem, John T. Harty
This study shows that an mRNA vaccine can overcome hemozoin-mediated impairment of RAS vaccine efficacy in malaria-exposed mice by restoring CD8+ T cell responses and protection.
bioRxiv · Oct 29, 2025 · PreprintMicrobiology