Stephen D. Liberles

Enteric sensory neurons for nutrient detection and gut motility

This study creates a single-cell atlas of the murine enteric nervous system, identifies molecularly defined IPANs, and shows their role in nutrient detection and gut motility regulation.

Vagal volume receptors in the heart compensate for blood loss and posture change

This study identifies vagal cardiac mechanoreceptors as critical for compensating blood loss and posture changes by regulating blood pressure.

Vagal TRPV1+ sensory neurons regulate myeloid cell dynamics and protect against influenza virus infection

This study shows TRPV1+ sensory neurons protect against influenza by modulating myeloid cell responses and reducing immunopathology.

Prox2+ and Runx3+ neurons regulate esophageal motility

The paper identifies and characterizes Prox2+ and Runx3+ vagal sensory neurons and shows their essential roles in esophageal peristalsis and swallowing.

Enteroendocrine cell lineages that differentially control feeding and gut motility

This study identifies the physiological roles of different enteroendocrine cell lineages in controlling feeding and gut motility using genetic and chemogenetic approaches.

Coordination of two enhancers drives expression of olfactory trace amine-associated receptors

The paper identifies two enhancers critical for TAAR gene expression in olfactory sensory neurons and shows they operate in cis to regulate gene choice.

Control of feeding by Piezo-mediated gut mechanosensation in Drosophila

This study identifies Drosophila Piezo as a mechanosensory receptor that controls meal size by detecting gut distension, with Piezo neuron activation reducing appetite and knockout increasing food intake.