Engineering transposon-associated TnpB-1 ωRNA system for efficient gene editing and disease treatment in mouse
Zhifang Li, Ruochen Guo, Xiao-Zhi Sun, Guoling Li, Yuanhua Liu, Xiaona Huo, Rongrong Yang, Zhuang Shao, Hainan Zhang, Weihong Zhang, Xiaoyin Zhang, Shuangyu Ma, Yinan Yao, Xinyu Liu, Hui Yang, , Chunlong Xu
This paper engineers a TnpB-ωRNA system for efficient gene editing in mice, showing improved activity over Cas12f1 and successful disease prevention in a tyrosinaemia model.
bioRxiv · Jun 29, 2023 · PreprintMolecular Biology