Recognition of RNA secondary structures with a programmable peptide nucleic acid-based platform
Rongguang Lu, Liping Deng, Yun Lian, Xin Ke, Lixia Yang, Kun Xi, Alan Ann Lerk Ong, Yanyu Chen, Hanting Zhou, Zhenyu Meng, Ruiyu Lin, Shijian Fan, Yining Liu, Desiree‐Faye Kaixin Toh, Xuan Zhan, , Gang Chen
This paper introduces daPNAs, a programmable platform combining dbPNAs and asPNAs to target RNA junctions, demonstrating their use in inhibiting Dicer and regulating ribosomal frameshifting.
Cell Reports Physical Science · Aug 12, 2024Peer-reviewedBiochemistry