Author

Franziska Kampshoff

Radboud University NijmegenORCID 0000-0002-5665-6979Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:Drosophila· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Organism:human· 1

Frequent Co-Authors

Annette SchenckiD· 3 shared Mireia Coll-TanéiD· 3 shared Spencer G. JonesiD· 3 shared Boyd van ReijmersdaliD· 2 shared Nicholas RauniD· 2 shared Tjitske KleefstraiD· 2 shared Amalia M. DolgaiD· 1 shared Ana SernaiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersGenetics

Annette SchenckORCID

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Author profile →

4 papers

Recent·Most cited

The evolutionarily conserved EHMT1/G9a histone methyltransferase family regulates sleep maintenance through ROS homeostasis in insulin-producing cells

Mireia Coll-Tané, Lara V. van Renssen, Nicholas Raun, Jie Han, Núria Ribas-Ros, Boyd van Reijmersdal, Jenny Luong, Chiara Pignato, Franziska Kampshoff, Naihua Natalie Gong, Spencer G. Jones, Sigrid Pillen, Anna Castells‐Nobau, Jordi Mayneris‐Perxachs, Marieke Klein, , Annette Schenck

This study identifies EHMT1/G9a's role in sleep regulation through ROS homeostasis in insulin-producing cells, linking it to sleep disturbances in Kleefstra syndrome and common insomnia.

bioRxiv · Sep 3, 2026 · PreprintGenetics

Metabolic collapse as a mechanism of developmental regression: convergent evidence from Kleefstra syndrome FDG-PET/CT imaging and Drosophila modelling

Spencer G. Jones, Arianne Bouman, Nicholas Raun, Evelien A. J. van Genugten, Isabel Martínez-Blázquez, Franziska Kampshoff, Janine Doorduin, Joyce M. Geelen, Hilgo Bruining, Karlijn Vermeulen, Stéphanie Miot, David Geneviève, Erik H.J.G. Aarntzen, Mireia Coll-Tané, Tjitske Kleefstra, Annette Schenck

This study links metabolic vulnerability and sleep disturbances in Kleefstra syndrome using FDG-PET/CT imaging and Drosophila models.

bioRxiv · Aug 31, 2026 · PreprintGenetics

A conserved epilepsy-associated gene co-expression module identifies increased metabolic rate as a shared pathomechanism

Jingyi Long, Spencer G. Jones, Ana Serna, Boyd van Reijmersdal, Franziska Kampshoff, Sara Aibar, Patrik Verstreken, Martijn A. Huynen, Kevin Lüthy, Mireia Coll-Tané, Annette Schenck

The paper identifies a conserved gene co-expression module in Drosophila linked to epilepsy, showing metabolic rate and AMPK activity influence seizure susceptibility.

Disease Models & Mechanisms · May 22, 2025Peer-reviewedNeuroscience

CACNA1A haploinsufficiency leads to reduced synaptic function and increased intrinsic excitability

Marina P. Hommersom, Nina Doorn, Sofía Puvogel, Elly Lewerissa, Annika Mordelt, Ummi Ciptasari, Franziska Kampshoff, Lieke Dillen, Ellen van Beusekom, Astrid R. Oudakker, Naoki Kogo, Amalia M. Dolga, Monica Frega, Dirk Schubert, Bart P.C. van de Warrenburg, , Hans van Bokhoven

This study characterizes a human neuronal model of CACNA1A haploinsufficiency, revealing synaptic deficits and increased intrinsic excitability linked to reduced potassium channel function.

Brain · Oct 26, 2024Peer-reviewedNeuroscience