Hélène Hirbec

Postprandial hypertriglyceridemia activates microglia to promote satiety via an ASC dependent signaling.

This study shows that postprandial hypertriglyceridemia activates microglia to promote satiety via an ASC-dependent signaling pathway, which is sexually dimorphic and disrupted in obesity.

Normal aging increases white matter microglial reaction and perivascular macrophages in the microcebe primate

This study examines age-related changes in microglia and perivascular macrophages in microcebe primates, finding increased HLA-DR+ expression in white matter and perivascular regions with aging.

Local translation controls early reactive changes in perisynaptic astrocyte processes at pre-symptomatic stages of Alzheimers disease

The paper identifies astrocyte perisynaptic processes as sites of early translational dysregulation in Alzheimer's disease, linking it to synaptic dysfunction and disease initiation.

APPNL-F knock-in Alzheimer's Disease model mice reveal etiological convergence of aging and amyloidosis

This study characterizes the early stages of amyloidosis and neuroinflammation in APPNL-F AD model mice, revealing a link between microglial senescence and disease progression.

Neuroprotection by chronic administration of Fluoroethylnormemantine (FENM) in mouse models of Alzheimer's disease

This study shows that chronic FENM infusion protects against Aβ25-35-induced neurotoxicity and improves memory in AD mouse models, with better efficacy than MEM.