Author

Dany Séverac

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 3 Genomics· 2 Bioinformatics· 1 Neuroscience· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 6 Approach:statistical model· 6 Assay:bulk RNA-seq· 5 Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Research Focus:clustering· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

Nicolas N NegreiD· 2 shared Anaïs Moulin· 1 shared Anaïs VignoniD· 1 shared Andrew OldfieldiD· 1 shared Anne-Laure Hemonnot-GirardiD· 1 shared Aubin Thomas· 1 shared Bernard BilloudiD· 1 shared Bernard DuviciD· 1 shared

Activity by Year

2014-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 4 mutual co-author links

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2 shared papersGenomics

Nicolas N NegreORCID

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Single-cell atlas reveals age-related cellular shifts underlying fibrosis in murine synovium

Olivier Bortolotti, Léa Marinèche, Bienfait Abasi-Ali, Dany Séverac, F. Leccia, Christophe Duperray, Lucas Brugioti, Jacques Colinge, Christelle Bertrand‐Gaday, Salwa Sebti, Florence Apparailly, Gabriel Courties

This study creates a single-cell atlas of murine ankle synovium across age, identifying age-related changes in fibroblasts and macrophages linked to fibrosis.

bioRxiv · Apr 21, 2026 · PreprintPhysiology

APPNL-F knock-in Alzheimer's Disease model mice reveal etiological convergence of aging and amyloidosis

Matthieu Prieur, Anne-Laure Hemonnot-Girard, Valentin Beck, Valentin Garcia, Thanawat Phuadraksa, Nathalie Linck, Manon Leportier, Anaïs Vignon, Dany Séverac, Véronique Perrier, François Rassendren, Marc Dhénain, Takashi Saito, Takaomi C. Saido, Hélène Hirbec

This study characterizes the early stages of amyloidosis and neuroinflammation in APPNL-F AD model mice, revealing a link between microglial senescence and disease progression.

bioRxiv · Jan 31, 2026 · PreprintNeuroscience

Analysis of a shark reveals ancient, Wnt dependent, habenular asymmetries in jawed vertebrates

Maxence Lanoizelet, Léo Michel, Ronan Lagadec, Hélène Mayeur, Lucile Guichard, Valentin Logeux, Dany Séverac, Kyle J. Martin, Christophe Klopp, Sylvain Marcellini, Héctor Castillo, Nicolas Pollet, Eva Candal, Mélanie Debiais‐Thibaud, Catherine Anne Boisvert, , Sylvie Mazan

This study identifies ancient Wnt-dependent habenular asymmetries in sharks, suggesting a conserved developmental mechanism across jawed vertebrates.

Nature Communications · Nov 25, 2024Peer-reviewedDevelopmental Biology

Major transcriptomic, epigenetic and metabolic changes underly the pluripotency continuum in rabbit preimplantation embryos

Wilhelm Bouchereau, Luc Jouneau, Catherine Archilla, Irène Aksoy, Anaïs Moulin, Nathalie Daniel, Nathalie Peynot, Sophie Caldérari, Thierry Joly, Murielle Godet, Yan Jaszczyszyn, Marine Pratlong, Dany Séverac, Pierre Savatier, Véronique Duranthon, , Nathalie Beaujean

This study maps the transcriptomic, epigenetic, and metabolic changes in rabbit preimplantation embryos, identifying novel markers of naive pluripotency and similarities to human and primate embryos.

Development · Aug 22, 2022Peer-reviewedDevelopmental Biology

H3K9me2 genome-wide distribution in the holocentric insect Spodoptera frugiperda (Lepidoptera: Noctuidae)

Sandra Nhim, Sylvie Gimenez, Rima Naït-Saïdi, Dany Séverac, Kiwoong Nam, Emmanuelle d’Alençon, Nicolas N Negre

The paper performs ChIP-Seq to analyze H3K9me2 distribution in S. frugiperda, finding it enriched at telomeres, rDNA, and satellite DNA but not correlated with transcriptional repression.

Genomics · Dec 28, 2021Peer-reviewedGenomics

TALC: Transcript-level Aware Long Read Correction

Lucile Broséus, Aubin Thomas, Andrew Oldfield, Dany Séverac, Emeric Dubois, William Ritchie

TALC improves long-read transcriptome correction by modeling RNA expression and isoform representation, enhancing downstream RNA-seq accuracy.

Bioinformatics · Jul 10, 2020Peer-reviewedBioinformatics

Spodoptera frugiperda transcriptional response to infestation by Steinernema carpocapsae

Louise Huot, Simon George, Pierre-Alain Girard, Dany Séverac, Nicolas N Negre, Bernard Duvic

The paper examines the transcriptional responses of Spodoptera frugiperda tissues to Steinernema carpocapsae infestation, identifying gene expression changes and potential immune effectors acquired via horizontal gene transfer.

Scientific Reports · Sep 9, 2019Peer-reviewedGenomics

Orb prevents autophagy in the Drosophila germline through translational repression of Atg12 mRNA

Isabelle Busseau, Stéphanie Pierson, Dany Séverac, Christelle Dantec, Martine Simonelig

This study shows Orb represses autophagy in Drosophila germline by inhibiting Atg12 mRNA translation, preventing cell death during early oogenesis.

bioRxiv · Aug 15, 2014 · PreprintDevelopmental Biology