Author

Luis Hernández-Huertas

Consejo Superior de Investigaciones Científicas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:zebrafish· 4 Research Focus:perturbation response prediction· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Miguel A. Moreno-MateosiD· 4 shared Ariel BazziniiD· 3 shared Ismael Moreno-SáncheziD· 3 shared Alejandro Díaz‐MoscosoiD· 2 shared Gabriel da Silva PescadoriD· 2 shared Gopal KushawahiD· 2 shared Laura Tomás‐GallardoiD· 2 shared Alejandra Cano-RuiziD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersDevelopmental Biology

Miguel A. Moreno-MateosORCID

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4 papers

Recent·Most cited

Rab8a-positive vesicles transport Wnt8a along cytonemes in zebrafish embryogenesis.

Gemma Sutton, Lucy H. Brunt, Jessica L. Bamsey, Luis Hernández-Huertas, Elizabeth Sears, Eloise Beaumont, Grace Patterson, Corin Liddle, Yuehua Chen, Miguel A. Moreno-Mateos, Steffen Scholpp

The paper shows Rab8a-dependent vesicular trafficking transports Wnt8a along cytonemes in zebrafish embryos, affecting Wnt signaling and embryonic patterning.

bioRxiv · Jun 6, 2026 · PreprintDevelopmental Biology

CRISPR-RfxCas13d screening uncovers Bckdk as a post-translational regulator of the maternal-to-zygotic transition in teleosts

Luis Hernández-Huertas, Ismael Moreno-Sánchez, Jesús Crespo-Cuadrado, Ana Vargas-Baco, Gabriel da Silva Pescador, Ying Zhang, Zhihui Wen, Laurence A. Florens, José M. Santos-Pereira, Ariel Bazzini, Miguel A. Moreno-Mateos

The paper uses CRISPR-RfxCas13d screening in zebrafish to identify Bckdk as a post-translational regulator of the maternal-to-zygotic transition, showing its role in ZGA and miR-430 processing.

The EMBO Journal · Nov 18, 2025Peer-reviewedDevelopmental Biology

Enhanced RNA-targeting CRISPR-Cas technology in zebrafish

Ismael Moreno-Sánchez, Luis Hernández-Huertas, Daniel Nahón-Cano, Pedro Manuel Martínez‐García, Anthony J. Treichel, Carlos Gómez-Marín, Laura Tomás‐Gallardo, Gabriel da Silva Pescador, Gopal Kushawah, Rhonda Egidy, Anoja G. Perera, Alejandro Díaz‐Moscoso, Alejandra Cano-Ruiz, John A. Walker, Manuel J. Muñoz, , Miguel A. Moreno-Mateos

This study optimizes CRISPR-Cas13d for RNA targeting in zebrafish by improving gRNA design, nuclear targeting, and computational prediction, reducing collateral effects.

Nature Communications · Mar 16, 2025Peer-reviewedDevelopmental Biology

CRISPR-Cas13d induces efficient mRNA knock-down in animal embryos

Gopal Kushawah, Luis Hernández-Huertas, Joaquín Abugattas-Núñez del Prado, Juan Ramón Martínez‐Morales, Michelle Lynn DeVore, Huzaifa Hassan, Ismael Moreno-Sánchez, Laura Tomás‐Gallardo, Alejandro Díaz‐Moscoso, Dahiana E. Monges, Javier R. Guelfo, William C. Theune, Emry O. Brannan, Wei Wang, Timothy J. Corbin, , Miguel A. Moreno-Mateos

This study demonstrates that CRISPR-Cas13d efficiently knocks down specific mRNAs in zebrafish, medaka, killifish, and mouse embryos, leading to significant transcript level reduction and embryonic phenotypes.

Developmental Cell · Aug 7, 2020Peer-reviewedDevelopmental Biology