Fine tuning of CpG spatial distribution with DNA origami for improved therapeutic cancer vaccination
Yang C. Zeng, Olivia J. Young, Christopher M. Wintersinger, Frances M. Anastassacos, James I. MacDonald, Giorgia Isinelli, Maxence O. Dellacherie, Miguel C. Sobral, Haiqing Bai, Amanda R. Graveline, Andyna Vernet, Melinda Sanchez, Kathleen Mulligan, Young–Jin Choi, Thomas C. Ferrante, , William M. Shih
This study developed a DNA origami-based cancer vaccine that co-delivers antigen and CpG immune adjuvant with an optimal nanospacing for Th1 immune polarization.
bioRxiv · Jun 8, 2022 · PreprintSynthetic Biology