Abdussalam Azem

Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress

The paper uses cryo-electron tomography to study structural changes in mitochondrial protein biogenesis under proteostatic stress, revealing remodeling of cristae and mHsp60 conformation.

Structural basis for ATP-driven double-ring assembly of the human mitochondrial Hsp60 chaperonin

The paper presents cryo-EM structures of human mitochondrial Hsp60 chaperonin in different states to elucidate the structural basis of ATP-driven double-ring assembly.

Biochemical and neurophysiological effects of deficiency of the mitochondrial import protein TIMM50

This study investigates the effects of TIMM50 deficiency in human fibroblasts and mouse neurons, finding reduced mitochondrial function and altered potassium channel levels linked to neurological symptoms.