Stephanus Theron Malherbe

Inflammatory Biomarkers of Asymptomatic and Symptomatic Tuberculosis

This study identifies transcriptomic and proteomic features of asymptomatic tuberculosis, revealing distinct sub-clusters and a new blood signature, but finds weaker diagnostic performance for asymptomatic cases compared to symptomatic ones.

Integration of immunomonitoring assays with PET/CT in TB patients identifies on-treatment biomarkers

The paper identifies on-treatment biomarkers in TB patients by integrating immunomonitoring assays with PET/CT scans, showing significant cytokine changes and machine learning-based biomarkers for treatment response.

Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis

The paper identifies gene pathways associated with neutrophil and platelet responses that are activated up to six months before TB diagnosis in whole blood.

cis-eQTL mapping of TB-T2D comorbidity elucidates the involvement of African ancestry in TB susceptibility

This study identifies ancestry-specific eQTLs in TB-T2D patients using cis-eQTL mapping, revealing variants associated with gene expression that could guide therapeutic targets in African populations.