Naiming Chen

This study identifies RIF1's role in restoring H3K9me3 post-replication by facilitating SUV39H1, HP1, and PP1 recruitment and restraining Aurora kinase activity.

This study uses supervised and unsupervised deep learning to analyze DNA replication dynamics in mouse cells, identifying altered patterns in Rif1-deficient cells and extending to patient samples.

This study identifies RIF1 as a molecular hub that co-regulates nuclear organisation and replication timing through its interaction with PP1, revealing distinct functional requirements for these processes.

This study shows that competence to epithelialise and differentiate in pluripotent cells is regulated by Tcf15, linking these processes through integrin alpha3 upregulation.

Nessys provides a method for accurate 3D nuclear segmentation in dense, heterogeneous tissues and tracks cell interactions during differentiation.