Takeshi Takarada

Stress-Responsive Protein IFRD1 Protects Assembled Ribosomes via a Ribosome-Salvaging Mechanism

This study identifies IFRD1 as a ribosome-salvaging factor that stabilizes non-translating 80S ribosomes during ER stress, preventing degradation and cell death.

The Role of Human-Specific lncRNA in Hyaline Cartilage Development

This study identifies human-specific lncRNAs upregulated in hyaline cartilage-like tissue derived from human iPS cells, suggesting their role in regulating extracellular matrix genes and potential applications in regenerative medicine.

SGCRNA: Spectral Clustering-Guided Co-Expression Network Analysis Without Scale-Free Constraints for Multi-Omic Data

SGCRNA improves upon WGCNA by removing scale-free constraints and parameter tuning, offering a more flexible co-expression network analysis for multi-omic data.

Scaffold-free cryopreservable cartilage grafts obtained from hiPSC-derived chondroprogenitor cells for airway reconstruction with growth adaptability

This study develops scaffold-free, cryopreservable cartilage grafts from hiPSC-derived cells for tracheal reconstruction, showing growth adaptability and superior performance in animal models.

Modeling human limb skeletal development using human pluripotent stem cell-derived skeletal assembloids

This study develops a method to generate human skeletal assembloids that recapitulate limb skeletal development and endochondral ossification with longitudinal growth.

The congenital multiple organ malformation syndrome, Ritscher-Schinzel syndrome is an endosomal recyclinopathy

This study identifies RSS as a recyclinopathy caused by dysfunction in the Commander endosomal recycling pathway, linking it to multiple tissue malformations.