Ruth A. Franklin

Type I interferon primes the alveolar epithelium to receive reparative signals from tissue-resident macrophages

The paper shows that type I interferon primes alveolar epithelial cells for regeneration by enhancing their response to reparative signals from tissue-resident macrophages after viral infection.

In vivo interrogation of transcriptional and epigenetic regulators of lung epithelial regeneration

The paper identifies Kat8 and the NSL complex as essential for lung epithelial repair and maps transcription factor dependencies in alveolar repair trajectories using SAGE.

Airway injury induces alveolar epithelial responses mediated by macrophages

This study shows that airway injury triggers alveolar type 2 cell proliferation mediated by macrophages, revealing a myeloid-driven response in the lung.

Vagal TRPV1+ sensory neurons regulate myeloid cell dynamics and protect against influenza virus infection

This study shows TRPV1+ sensory neurons protect against influenza by modulating myeloid cell responses and reducing immunopathology.

Principles of Cell Circuits for Tissue Repair and Fibrosis

This study identifies a cell-circuit framework for wound healing and fibrosis, revealing three fibrosis outcomes and parameters that control the transition from healing to fibrosis.