Pharmacology & ToxicologybioRxivPreprint
Cyclooxygenase-2 disruption predisposes to heart failure with preserved ejection fraction
Emanuela Ricciotti, Philip G. Haines, Manu Beerens…·Garret A. FitzGerald
This study shows that COX-2 deletion or inhibition leads to heart failure with preserved ejection fraction in zebrafish, mice, and humans.