Cyclooxygenase-2 disruption predisposes to heart failure with preserved ejection fraction
Emanuela Ricciotti, Philip G. Haines, Manu Beerens, Uri Kartoun, Cecilia Castro, Soon Yew Tang, Soumita Ghosh, Ujjalkumar Subhash Das, Nicholas F. Lahens, Tao Wang, Jules L. Griffin, Stanley Y. Shaw, Calum A. MacRae, Garret A. FitzGerald
This study shows that COX-2 deletion or inhibition leads to heart failure with preserved ejection fraction in zebrafish, mice, and humans.
bioRxiv · Sep 28, 2024 · PreprintPharmacology & Toxicology