David VanInsberghe

Viral dispersal drives changes in population composition

The paper investigates how spatial expansion and dispersal modulators affect viral population structure and genetic diversity during infection.

Within-host antigenic selection of influenza A virus dominates over stochasticity but is limited by fitness tradeoffs and timing of the immune response

This study shows that antigenic selection of influenza virus within hosts is driven by immune pressure timing and fitness tradeoffs, with moderate stochastic effects observed.

Comparative analysis of flavivirus sfRNA dynamics and secondary structure

This study compares sfRNA secondary structure dynamics in vitro and in infected cells across multiple flaviviruses, identifying conserved and variable structural features.

SARS-CoV-2 5'-UTR stem-loops activate the antiviral protein oligoadenylate synthetase 1 (OAS1)

This study identifies a conserved SARS-CoV-2 5-UTR stem-loop region that activates OAS1, a key antiviral protein, through structural and functional analyses.

Within-host adaptive evolution is limited by genetic drift in experimental human influenza A virus infections

This study examines within-host evolutionary dynamics of influenza A virus in humans and ferrets, finding that genetic drift limits selection efficiency in humans but not in ferrets.

Viral lineage and mode of exposure modulate within host spatial dynamics of influenza A viruses

This study shows that influenza A virus lineage and exposure route affect its spatial distribution and genetic diversity within the respiratory tract of guinea pigs.

Virion aggregation shapes infection dynamics and evolutionary potential

This study investigates how viral aggregation affects infection dynamics and genetic diversity in mammalian orthoreovirus, finding that it reduces replicative potential but increases evolutionary potential through reassortment.

Towards a potential landscape framework of microbiome dynamics

This paper introduces a topological data analysis framework to model microbiome dynamics, identifying state transitions linked to health and environmental processes.