Yan He

The paper identifies J-domain proteins as mediators of PKL recruitment to gene promoters, enabling H3.3 deposition and influencing gene expression through interactions with transcription factors and ATRX.

SunTag-NOVA, a SunTag-MQ1v editor adding TRBIP1 and an oligomerizing CHLAMY domain, methylates and silences FWA, FT and TMM in Arabidopsis without the genome-wide off-target methylation seen with TRBIP1 alone.

The paper tests two CRISPR-based epigenome editing tools in cassava to induce DNA methylation at susceptibility gene promoters, reducing pathogen infection and showing inheritance patterns.

This study shows that VAMP8 depletion impairs clathrin-mediated endocytosis by disrupting endocytic cargo recycling and rerouting it to lysosomal degradation.