Author

Dorothee Childs

European Molecular Biology LaboratoryORCID 0000-0002-2432-4128Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Wolfgang K. HuberiD· 2 shared Aleksandar BartolomeiD· 1 shared Alessandro CellerinoiD· 1 shared Alessandro Ori‬‬iD· 1 shared Cinzia CaterinoiD· 1 shared Domenico Di FraiaiD· 1 shared Erika Kelmer SacramentoiD· 1 shared Eva Terzibasi TozziniiD· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersSystems Biology

Wolfgang K. HuberORCID

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2 papers

Recent·Most cited

Systems BiologyMolecular Systems BiologyPeer-reviewedJun 1, 2020

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

Erika Kelmer Sacramento, Joanna M Kirkpatrick, Mariateresa Mazzetto…·Alessandro Ori‬‬

This study shows that reduced proteasome activity in aging brains leads to ribosome stoichiometry loss and aggregation, increasing mortality risk in killifish.

236 citationstop 1%

proteomicsbulk RNA-seq

BioinformaticsMolecular & Cellular ProteomicsPeer-reviewedOct 3, 2019

Non-Parametric Analysis of Thermal Proteome Profiles Reveals Novel Drug-Binding Proteins

Dorothee Childs, Karsten Bach, Holger Franken…·Wolfgang K. Huber

This paper introduces NPARC, a non-parametric method for analyzing thermal proteome profiles to identify drug-binding proteins with improved specificity and sensitivity.

103 citationstop 2%

proteomicsstatistical model