Eva Terzibasi Tozzini

This study examines cardiac aging in Greenland sharks, finding fibrosis, lipofuscin, and oxidative damage but no physiological decline, suggesting resilience to aging.

The paper presents a chromosome-level genome assembly of the Greenland shark and identifies genomic features associated with its extreme longevity.

The paper confirms age-dependent noradrenergic neuron degeneration in killifish, with early phospho-Synuclein presence, but not dopaminergic neuron loss.

This paper demonstrates that TDP-43 paralogs in the killifish N. furzeri form amyloid-like aggregates during ageing, suggesting the fish as a model for TDP-43-related neurodegenerative diseases.

This study shows that reduced proteasome activity in aging brains leads to ribosome stoichiometry loss and aggregation, increasing mortality risk in killifish.

This study shows miR-29 regulates iron homeostasis in the brain by reducing iron uptake, preventing excessive accumulation and age-related damage.