Author

Holger Franken

GlaxoSmithKline (Germany)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Marcus BantscheffiD· 2 shared Mikhail M. SavitskiiD· 2 shared Nils KurzawaiD· 2 shared Simon AndersiD· 2 shared Wolfgang K. HuberiD· 2 shared Aikaterini GeladakiiD· 1 shared Alessandro Di Tullio· 1 shared André MateusiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioinformatics

Marcus BantscheffORCID

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3 papers

Recent·Most cited

High-throughput platforms for genetic perturbation screening using CRISPR/Cas9 in human iPSC-derived macrophages for drug discovery

Matteo Martufi, Eleni Karagianni, Tasos Papanikos, Tim G. Ashlin, Aikaterini Geladaki, Benedetta Carbone, Katja S. Remlinger, Andres Quintero Moreno, William G. Pembroke, Charlie Haslam, Nico Zinn, Denise F. Vlachou, Margarida Almeida, Dimitrios Tsaousis, Stephan Gade, , Lisa Mohamet

The paper establishes a CRISPR/Cas9 screening platform in hiPSC-derived macrophages to identify genetic targets influencing inflammatory responses and functional phenotypes.

bioRxiv · Sep 14, 2026 · PreprintImmunology

Computational analysis of ligand dose range thermal proteome profiles

Nils Kurzawa, Isabelle Becher, Sindhuja Sridharan, Holger Franken, André Mateus, Simon Anders, Marcus Bantscheff, Wolfgang K. Huber, Mikhail M. Savitski

The paper develops a statistical method to analyze thermal proteome profiles and identifies off-target drug interactions in epigenetic drugs.

Nature Communications · Nov 13, 2020Peer-reviewedBioinformatics

Non-Parametric Analysis of Thermal Proteome Profiles Reveals Novel Drug-Binding Proteins

Dorothee Childs, Karsten Bach, Holger Franken, Simon Anders, Nils Kurzawa, Marcus Bantscheff, Mikhail M. Savitski, Wolfgang K. Huber

This paper introduces NPARC, a non-parametric method for analyzing thermal proteome profiles to identify drug-binding proteins with improved specificity and sensitivity.

Molecular & Cellular Proteomics · Oct 3, 2019Peer-reviewedBioinformatics