Shreyasi Chatterjee

This paper observes conformational dynamics of unmodified IDPs/IDRs at the single-molecule level using nanoaperture optical tweezers, revealing increased conformational variation and phosphorylation-induced compaction.

The paper examines age-related changes in tau and autophagy in cognitively normal individuals without neurodegeneration, finding reduced soluble tau and potential autophagy involvement.

This paper develops a peptide inhibitor, RI-AG03, that reduces Tau aggregation in vitro and improves Tauopathy symptoms in Drosophila.

This study creates a Drosophila model expressing codon-optimized human TDP-43, showing neurodegenerative phenotypes and toxic protein aggregation.