Author

Jonathan Z. Huang

Princeton University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioinformatics· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Mohammad R. SeyedsayamdostiD· 4 shared Vanessa Y. YingiD· 4 shared Alden R. WeineriD· 1 shared Andrew D. WhiteiD· 1 shared Andy K. L. NguyiD· 1 shared Bonnie L. BassleriD· 1 shared Brandon L. GreeneiD· 1 shared Chase M. KayrouziD· 1 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersBiochemistry

Mohammad R. SeyedsayamdostORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Small molecule structure elucidation from NMR spectra with generative and reasoning models

Ziyu Xiong, Vanessa Y. Ying, Jonathan Z. Huang, Zane Koch, Joseph D. Clark, Robert C. Heeter, Joon Soo An, Karit Matanachai, Samuel G. Rodriques, Andrew D. White, Mohammad R. Seyedsayamdost, Ellen D. Zhong

This paper introduces an AI system for automated small molecule structure elucidation from NMR spectra, combining generative models with reasoning agents to outperform existing tools.

bioRxiv · Oct 31, 2026 · PreprintBioinformatics

Non-Canonical Cytochrome P450 Enzymes in Nature

Andy K. L. Nguy, Kendra A. Ireland, Chase M. Kayrouz, Juan Carlos Caceres, Jonathan Z. Huang, Vanessa Y. Ying, Joanna Afokai Quaye, Brandon L. Greene, Katherine M. Davis, Mohammad R. Seyedsayamdost

The paper identifies and characterizes non-canonical CYPs lacking the conserved cysteine ligand, revealing new ligands like serine and selenocysteine in microbial genomes.

Nature Chemical Biology · Jun 22, 2026Peer-reviewedBiochemistry

Caenorhabditis elegans avoids Todstoff, a novel nociceptive necrotaxis cue

Erik Toraason, Rachel L. Kaletsky, Jonathan Z. Huang, Vanessa Y. Ying, Xuanjia Ye, Edoardo José Longarini, Alden R. Weiner, Waasae Ayyaz, Pablo Ramirez-Garcia, Tom W. Muir, Mohammad R. Seyedsayamdost, Coleen Tara Murphy

This study identifies Todstoff, a novel aversive cue in C. elegans that induces necrotaxis behaviors by signaling through ASH neurons and GPCR pathways.

bioRxiv · Feb 10, 2026 · PreprintGenetics

Discovery of a Human Metabolite that Mimics the Bacterial Quorum-Sensing Autoinducer AI-2

Emilee E. Shine, Julie S. Valastyan, Vanessa Y. Ying, Jonathan Z. Huang, Mohammad R. Seyedsayamdost, Bonnie L. Bassler

This study identifies L-xylosone as a human metabolite that mimics the bacterial quorum-sensing autoinducer AI-2, revealing a new host-microbe interaction.

Journal of the American Chemical Society · Feb 4, 2026Peer-reviewedBiochemistry