Alexander Gerbaulet

The paper uses fate-mapping, single-cell RNA-sequencing, and computational methods to show that major hematopoietic lineages diverge within HSCs, identifying a self-renewing HSC subpopulation and a direct thrombopoiesis pathway.

This study develops an in-silico model to explore how hematopoietic stem cells (HSCs) respond to varying demands and aging, showing that internal feedback between HSCs and progenitors explains homeostasis and aging-related changes.