Sébastien Léon A

The paper identifies PAX3's role in coupling metabolism and cell mechanics during neuroepithelial morphogenesis, showing mannose metabolism is critical for adherens junction function.

This study identifies Reg1 mutations that confer resistance to 2-deoxyglucose in yeast by disrupting its role in Snf1 inhibition.

This paper demonstrates a method to directly detect and quantify fluorescent proteins in gels, offering a faster, cheaper, and more sensitive alternative to immunoblotting.

This paper investigates how 2-deoxyglucose (2DG) induces endocytosis of plasma membrane proteins in yeast, revealing a role for the Snf1/AMPK pathway and Rod1 in mediating 2DG resistance.

The paper introduces NUbiCA, a sensitive protein-fragment complementation assay for detecting ubiquitylation events in cultured cells and model organisms, demonstrating its application to study Cse4 ubiquitylation during S-phase.

This paper identifies Dog1 and Dog2 as 2DG detoxication enzymes in yeast, showing their regulation by signaling pathways and their role in 2DG resistance, with implications for human cancer therapy.