Latha Velayudhan

Endocannabinoid System Genes in Dementia: A Systematic Mendelian Randomization Study of Functional Variants and Tissue-Specific Expression Across Clinical, Molecular, and Neuroimaging Phenotypes

This study uses Mendelian randomization to investigate ECS gene variants and their associations with dementia risk and biomarkers, finding some links but no strong causal evidence.

Investigating the genetic relationship between depression symptoms and Alzheimer's disease in clinically diagnosed and proxy cases

This study investigates the genetic relationship between depression symptoms and Alzheimer's disease using GWAS and finds significant genetic correlations but no causal link, suggesting proxy cases may drive the overlap.

Neuroanatomical substrates in Parkinson's Disease psychosis and their association with serotonergic receptor gene expression: A coordinate-based meta-regression analysis.

This study identifies parieto-temporo-occipital cortical volume loss in Parkinson's Disease psychosis and links it to serotonergic receptor gene expression.

Assessing genetic overlap and causality between blood plasma proteins and Alzheimer's Disease

This study investigates genetic overlap and causality between blood plasma proteins and Alzheimer's Disease using polygenic risk scores and Mendelian Randomization, finding associations but no strong causal links.

Largest GWAS (N=1,126,563) of Alzheimer's Disease Implicates Microglia and Immune Cells

This study identifies seven novel genetic loci for Alzheimer's disease using a large GWAS and highlights microglia and immune pathways as key contributors to disease pathology.

Integrated lipidomics and proteomics network analysis highlights lipid and immunity pathways associated with Alzheimer's disease

The paper integrates lipidomics and proteomics data to identify modules associated with Alzheimer's disease phenotypes and risk loci in immune and lipid pathways.