Andreas T. Schaefer

`Silent' mitral cells emerge from common feature subtraction

The paper explains 'silent' mitral cells in the olfactory bulb using a computational model that incorporates common feature subtraction, showing baseline activity cancels common olfactory features to enhance odor response.

Decorrelation by gain control in the mouse olfactory bulb

The paper shows that the mouse olfactory bulb decorrelates odour representations from input to output, enhancing separability through gain modulation.

A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain

The paper shows that olfactory receptor expression in the nose follows a spatial code controlled by a retinoic acid gradient, aligning epithelial and brain maps.

Decomposing representational drift across wake and sleep

This study decomposes representational drift in mice olfactory cortex during wake and sleep, showing distinct transformations driven by each state.

Critical point drying of brain tissue for X-ray phase contrast imaging

This paper demonstrates that critical point drying enhances X-ray phase contrast in mouse brain tissue, improving imaging resolution and compatibility with further processing techniques.

Mice discriminate odour source distance via sub-sniff temporal features of odour plumes

This study shows mice can distinguish odour sources at different distances by analyzing rapid temporal features of odour plumes, with neural responses correlating more strongly with high-frequency plume features than mean concentration.

Structure-Function Mapping of Olfactory Bulb Circuits with Synchrotron X-ray Nanotomography

The paper uses synchrotron X-ray nanotomography to link subcellular anatomy to odor response diversity in mouse olfactory bulb projection neurons.

3D spatial transcriptomics reveals the molecular structure of input and output pathways in the mouse olfactory bulb

The paper uses 3D spatial transcriptomics to map the molecular organization of the mouse olfactory bulb, revealing symmetric glomeruli and asymmetric deeper layer cells.

Self-supervised image restoration in coherent X-rayneuronal microscopy

This paper introduces a self-supervised image restoration method for X-ray holographic nanotomography to improve resolution, contrast, and speed in neuronal imaging.

Robust encoding of sub-sniff temporal information in the mouse olfactory bulb

The paper investigates how temporal information from odour stimuli is encoded in mouse olfactory bulb neurons, finding a consistent temporal resolution and separable encoding of odour quality and dynamics.

Coherent olfactory bulb gamma oscillations arise from coupling independent columnar oscillators

The paper investigates the dynamical mechanisms of gamma oscillations in the olfactory bulb of mice, showing they arise from coupled columnar oscillators that enable coherent network activity.

Non-destructive X-ray tomography of brain tissue ultrastructure

This paper introduces engineering solutions to enable non-destructive X-ray tomography of brain tissue at ultrastructural resolution, validated against electron microscopy.

Wireless monitoring of respiration with EEG reveals relationships between respiration, behaviour and brain activity in freely moving mice

This study develops a wireless respiration monitoring technique in mice and shows its relationship with behaviour and brain activity during exploration and different sleep states.

Femtosecond laser preparation of resin embedded samples for correlative microscopy workflows in life sciences

The paper demonstrates the use of a femtosecond laser to prepare resin-embedded samples for correlative microscopy workflows, enabling precise targeting and trimming for high-resolution imaging techniques.

Sample preparation and warping accuracy for correlative multimodal imaging in the mouse olfactory bulb using 2-photon, synchrotron X-ray and volume electron microscopy

Coupling of mouse olfactory bulb projection neurons to fluctuating odour pulses

This study shows that mouse olfactory bulb projection neurons encode temporal odour frequency features up to 20 Hz, with coupling influenced by circuit properties.

Sparse connectivity for MAP inference in linear models using sister mitral cells

The paper proposes a method for MAP inference in linear models using sparse connectivity, inspired by sister mitral cells in the olfactory system.

Molecular characterization of projection neuron subtypes in the mouse olfactory bulb

The paper identifies molecular markers and gene regulatory mechanisms for projection neuron subtypes in the mouse olfactory bulb using single nucleus and bulk RNA sequencing.

Functional and multiscale 3D structural investigation of brain tissue through correlative in vivo physiology, synchrotron micro-tomography and volume electron microscopy

CHIME: CMOS-hosted in-vivo microelectrodes for massively scalable neuronal recordings

The paper introduces CHIME, a scalable neuronal recording system using microwires and CMOS arrays to overcome limitations in capturing neural activity in mammalian brains.

Massively Parallel Microwire Arrays Integrated with CMOS chips for Neural Recording

The paper introduces a neural recording system combining microwire arrays with CMOS chips to enable high-density, three-dimensional neural interfaces.

jULIEs: extracellular probes for recordings and stimulation in the structurally and functionally intact mouse brain

The paper introduces jULIEs, a new type of ultramicroelectrode that enables high signal-to-noise neural recordings and stimulation in intact mouse brains with minimal tissue damage.

Mammalian olfaction is a high temporal bandwidth sense

The paper demonstrates that mammals can perceive temporal structure in odour stimuli at fast timescales, using a novel odour delivery system and behavioural experiments with mice.

AutonoMouse: High throughput automated operant conditioning shows progressive behavioural impairment with graded olfactory bulb lesions.

The paper introduces an automated system for high-throughput operant conditioning in mice and uses it to study the effects of olfactory bulb lesions on behavior.

Rapid task-dependent tuning of the mouse olfactory bulb

This study shows the mouse olfactory bulb dynamically modulates neural responses based on stimulus tuning to enhance discriminability under different behavioural demands.

Sniff-invariant intensity perception using olfactory bulb coding of inhalation dynamics

The paper shows that mice use olfactory bulb mitral and tufted cells to encode inhalation dynamics, enabling odor intensity perception independent of sniffing variability.

Active sampling state dynamically enhances olfactory bulb odor representation

The paper shows that active sampling state enhances odor representation in the olfactory bulb during rapid learning.