Yu‐Wei Wu

Electrode pooling preserves movement decoding by retaining neural population dynamics

This study evaluates electrode pooling in mouse sensorimotor cortex, finding that while some neuronal detail is lost, population dynamics for movement decoding are preserved.

Ultra-sensitive measurement of brain penetration mechanics and blood vessel rupture with microscale probes

The paper measures insertion mechanics and vascular responses of microscale neural probes in vivo, finding constant insertion force post-pia penetration and vessel displacement avoiding rupture at small scales.

A Distinct Layer 1 Astrocyte Program Shapes Perisynaptic Structure and Calcium Signaling in Mouse Motor Cortex

The paper identifies a distinct Layer 1 astrocyte program in mouse motor cortex linked to specialized structure and calcium signaling, showing that Id1/Id3 deletion disrupts this program.

Spatiotemporal differences of GABAergic polarization and shunting during dendritic integration

The paper investigates how GABAergic inputs influence dendritic integration through spatiotemporal differences in polarization and shunting in rat hippocampal neurons.

Refinement of efficient encodings of movement in the dorsolateral striatum throughout learning

This study shows that striatal ensembles become more efficient over learning by refining activation patterns in dSPNs and iSPNs in head-fixed mice.

CASTLE: a training-free foundation-model pipeline for cross-species behavioral classification

CASTLE is a training-free pipeline for cross-species behavioral classification that uses foundation models and ROI masking to achieve high accuracy without manual labeling.

Mixed Selectivity of Subthalamic Nucleus Neurons in Encoding Motor and Reward Behaviors

This study investigates how STN neurons encode motor and reward behaviors through mixed selectivity, revealing distinct encoding properties compared to the zona incerta.

Motor learning selectively strengthens cortical and striatal synapses of motor engram neurons

This study identifies synaptic plasticity in motor engram neurons during motor learning, showing increased spine density and connectivity to striatal neurons.

Massively Parallel Microwire Arrays Integrated with CMOS chips for Neural Recording

The paper introduces a neural recording system combining microwire arrays with CMOS chips to enable high-density, three-dimensional neural interfaces.

Tonic GABAA conductance favors temporal over rate coding in the rat hippocampus

This study investigates how tonic GABAA conductance influences different forms of synaptic plasticity, showing distinct effects on spike-timing-dependent and rate-based LTP in rat hippocampal neurons.

Morphological profile determines the frequency of spontaneous calcium events in astrocytic processes

The paper identifies that thin astrocytic processes with high surface-to-volume ratios generate more spontaneous Ca2+ events due to increased baseline fluctuations and CICR.

Ultra-sensitive measurement of brain penetration with microscale probes for brain machine interface considerations

This study measures brain penetration forces and tissue compression using microscale probes to inform better brain-machine interface design.