George G. Malliaras

SpiraMed: A Stereotactic Helix-based Therapy Delivery system for the Human Brain

SpiraMed improves brain therapy delivery by using a helical catheter system that enhances coverage and reduces reflux and bleeding risks.

A Dual-Gate OECT Platform for Drift-Suppressed and High-Sensitivity Real-Time Biosensing

This paper introduces a dual-gate OECT platform that suppresses drift and improves sensitivity for real-time biosensing in complex environments.

NeuroSuite for Long-term Functional and Structural Studies of Air-Liquid Interface Cerebral Organoids

NeuroSuite provides a non-invasive platform for long-term electrophysiological monitoring of brain organoids, revealing neural network development and activity changes.

Integrating Electrical Components into a Printed Self-folding Cuff Electrode for Chronic Peripheral Nerve Interfaces

This paper introduces a printed self-folding cuff electrode with integrated rigid electrical components for chronic peripheral nerve interfacing, demonstrating reliable nerve recordings in locusts and rats.

Implantable Bioelectronics for Gut Electrophysiology

This paper introduces a bioelectronic implant for recording neural activity in the distal colon of freely-moving rats, demonstrating its ability to capture electrophysiological responses and colonic activity related to food intake and stress.

PEDOT:PSS conducting eutectogel for enhanced electrical recording and stimulation in implantable neural interfaces

This paper introduces a PEDOT:PSS-based eutectogel for neural interfaces, showing improved impedance and charge injection capacity in vitro and enhanced electrophysiology in vivo.

Development of novel signal and spike velocity analysis tools in peripheral nerve cuffs

This paper introduces two novel signal analysis techniques for peripheral nerve recordings and demonstrates their ability to detect low signal-to-noise ratio signals and extract velocity information.

Ultraconformable cuff implants for long-term bidirectional interfacing of peripheral nerves at sub-nerve resolutions

This paper develops ultraconformable cuff implants for long-term bidirectional nerve interfacing in rats, achieving high-resolution recording and modulation of nerve activity.

Machine learning-based spike sorting reveals how subneuronal concentrations of monomeric Tau cause a loss in excitatory postsynaptic currents in hippocampal neurons

The paper introduces PseudoSort, a machine learning algorithm for spike sorting, and applies it to MEA data from hippocampal neurons exposed to monomeric Tau, revealing its impact on neuronal activity.

Regenerative capacity of neural tissue scales with changes in tissue mechanics post injury

This study investigates how mechanical properties of neural tissue change after injury, finding that PNS tissue stiffens while CNS tissue softens, potentially influencing regeneration.

NeuroRoots, a bio-inspired, seamless Brain Machine Interface device for long-term recording.

NeuroRoots is a bio-inspired, multi-channel implant that enables long-term stable neural recording in rats, maintaining signal quality for at least 7 weeks.