LRRK2 mutations block NCOA4 trafficking upon iron overload leading to ferroptotic death
Andrés Goldman, Mai Nguyen, Joël Lanoix, Chongyang Li, Ahmed M. Fahmy, Yong Zhong Xu, Erwin Schurr, Pierre Thibault, Michel Desjardins, Heidi May McBride
The paper shows LRRK2 mutations impair NCOA4 trafficking during iron overload, causing ferroptotic cell death in macrophages.
Journal of Cell Science · May 28, 2026Peer-reviewedCell Biology