Ruonan Zhao

This study identifies NR6A1 as a critical regulator of mammalian neural crest cell specification, formation, and survival through loss-of-function experiments and multiomic analyses.

The paper identifies and characterizes intermediate states during neural crest cell epithelial to mesenchymal transition and delamination using single-cell RNA sequencing.

The paper identifies a novel mechanism of neural crest cell delamination through cell extrusion, revealing PIEZO1's role in this process in mouse embryos.

The paper shows that disruptions in Pol I rRNA transcription specifically affect craniofacial development by causing NCC apoptosis and craniofacial anomalies in mice.