Kristin E. Noack Watt

This study shows that loss of polr1c in zebrafish causes reduced myelination and craniofacial defects, with Tp53 pathway activation but no apoptosis in oligodendrocyte precursors.

This study investigates the role of Polr3a in craniofacial development using zebrafish mutants, finding hypoplasia of craniofacial cartilage and bone due to reduced tRNA transcription and ribosome biogenesis.

This study demonstrates the use of updated nanopore sequencing to characterize 43 RNA modifications in tRNAs, including mitochondrial and viral tRNAs, and provides best practices for future research.

The paper shows that disruptions in Pol I rRNA transcription specifically affect craniofacial development by causing NCC apoptosis and craniofacial anomalies in mice.