Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator
Ahmed S. Abdelfattah, Jihong Zheng, Amrita Singh, Yi-Chieh Huang, Daniel Reep, Getahun Tsegaye, Arthur Tsang, Benjamin J. Arthur, Monika Řehořová, Carl V.L. Olson, Yichun Shuai, Lixia Zhang, Tian-ming Fu B, Daniel Edward Milkie, Maria V. Moya, , Ilya Kolb
The paper identifies a mutation that enhances the sensitivity of a fluorescent voltage indicator, improving its ability to detect both spiking and subthreshold voltage signals in multiple organisms.
Neuron · Apr 3, 2023Peer-reviewedNeuroscience