Ahmed S. Abdelfattah

This paper introduces two new far-red fluorescent GECIs, FR-GECO1a and FR-GECO1c, characterized for their Ca2+ sensitivity and performance in neuronal imaging.

The paper introduces a novel rhodopsin-based voltage indicator, 2Photron, enabling simultaneous two-photon recording of spiking and subthreshold voltage with GCaMP in awake mice.

This paper introduces ORCHID, an all-optical method to measure inhibitory receptor driving forces, demonstrating its accuracy and application in neurons and astrocytes.

The paper identifies a mutation that enhances the sensitivity of a fluorescent voltage indicator, improving its ability to detect both spiking and subthreshold voltage signals in multiple organisms.

The paper describes engineering eFRET voltage indicators with positive-going fluorescence responses by modifying microbial rhodopsins.

The paper introduces a new platform for chemigenetic fluorescent indicators with bright, far-red emission and tunable properties for detecting single action potentials in neurons.

The paper introduces rsCaMPARI, an erasable neuronal activity marker that allows for marking, erasing, and remarking of active neuron populations in zebrafish.

The paper introduces a new genetically encoded voltage indicator, Voltron, which improves brightness and photostability for extended in vivo voltage imaging in mice, zebrafish, and fruit flies.

This paper introduces a two-photon imaging technique that achieves high-speed, high-resolution imaging of neural activity in mice at over 1 kHz frame rates.

The paper develops tools for wide-area mapping of neuronal activity in brain slices using optimized optogenetic tools and structured illumination.