Rui Gao

Deciphering the gene-centric spatial dynamics across tissue and time with GeneSPOT

GeneSPOT is a gene-centric framework that characterizes spatial gene relationships and their reorganization across biological conditions and time.

Senescence-associated KRAS upregulation in peripheral T cells links to premature coronary artery disease

The paper identifies KRAS upregulation in senescent CD8+ T cells as linked to premature coronary artery disease through single-cell and bulk transcriptomic analyses.

Defining the Immunomodulatory Determinants of 3-mer Oligonucleotides on TLR7 and TLR8 sensing

The paper identifies how 3-mer oligonucleotides with base and sugar modifications modulate TLR7 and TLR8 responses, leading to the development of a dual inhibitory oligonucleotide for autoimmune disease.

MEST inhibits ciliary sphingomyelin synthesis to promote tendon stem/progenitor cells osteochondrogenesis in traumatic heterotopic ossification

This study identifies MEST's role in promoting tHO by inhibiting ciliary sphingomyelin synthesis and enhancing Hh signaling in TSPCs.

2'-O-Methyl-guanosine 3-base RNA fragments mediate essential natural TLR7/8 antagonism

The paper identifies 2'-O-methyl-guanosine RNA fragments as natural antagonists of TLR7/8, preventing auto-immunity by inhibiting TLR signaling.

Bridging the Dimensional Gap from Planar Spatial Transcriptomics to 3D Cell Atlases

SpatialZ generates dense 3D cell atlases from planar spatial transcriptomics data by reconstructing virtual slices, validated with real 3D data and enabling new spatial analyses.

Phase separation of Polycomb-like (PCL) proteins drive PRC2 complex condensates to regulate gene expression

This study shows PCL proteins phase-separate to form PRC2 condensates, regulated by CpG islands disrupting their intramolecular interactions.

Homoharringtonine Promotes FTO Degradation to Suppress LILRB4-Mediated Immune Evasion in Acute Monocytic Leukemia

This study shows that homoharringtonine promotes FTO degradation, reducing LILRB4 expression and enhancing immune recognition in acute monocytic leukemia.

Deconer: A comprehensive and systematic evaluation toolkit for reference-based cell type deconvolution algorithms using gene expression data

Deconer evaluates reference-based cell type deconvolution methods using simulated and real gene expression data, comparing 14 methods across multiple criteria and providing guidance for users.

Rnf20 shapes the endothelial control of heart morphogenesis and function

This study identifies Rnf20's role in regulating cardiac morphogenesis and function through endothelial mechanisms, revealing its impact on extracellular matrix dynamics and angiocrine signaling.