Tim F. Cootes

Dissecting the genetic architecture of knee alignment reveals its contribution to osteoarthritis risk

This study identifies 20 genetic loci associated with knee alignment and shows genetic correlation with knee osteoarthritis, suggesting osteoarthritis may causally influence alignment.

Genome-wide association study of DXA-derived hip morphology identifies associations with 4 loci in Chinese populations

This study identifies four genetic loci associated with hip morphology in Chinese populations through GWAS, with two loci previously linked to musculoskeletal development and two being novel findings.

Hip joint space width is causally related to hip osteoarthritis risk via distinct protective and susceptibility mechanisms: findings from a genome-wide association study meta-analysis

This study identifies genetic determinants of hip joint space width and finds they have opposing causal effects on hip osteoarthritis risk through distinct mechanisms.

Measuring vision using innate behaviours in mice with intact and impairedretina function

This study develops automated methods to measure vision in mice using innate defensive responses, showing they can assess visual acuity and detect retinal dysfunction.