Author

Sumera Irie Ilyas

Mayo ClinicORCID 0000-0002-2709-3003Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Danielle Marie CarlsoniD· 3 shared Rory L. SmootiD· 3 shared Akhilesh PandeyiD· 2 shared Amro M. AbdelrahmaniD· 2 shared Binbin LiiD· 2 shared Dong‐Gi MuniD· 2 shared Enis H. OzmertiD· 2 shared Erik JesseniD· 2 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Danielle Marie CarlsonORCID

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Author profile →

3 papers

Recent·Most cited

ESCRT-dependent YAP degradation by AKT blockade overcomes adaptive resistance to RAS(ON) inhibition in pancreatobiliary cancer

Jack W. Sample, Enis Özmert, Brandon A. Wilbanks, Danielle Marie Carlson, Hidemi Nishi, Amro M. Abdelrahman, Erik Jessen, Meina Cai, Dong‐Gi Mun, Hendrien Kuipers, Anna Splinter, Alexander L. Ticho, Nathan W. Werneburg, Akhilesh Pandey, Mark Joseph Truty, , Rory L. Smoot

This study identifies AKT as a regulator of YAP stability and shows that AKT inhibition triggers ESCRT-dependent YAP degradation, enhancing the efficacy of RAS inhibition in pancreatobiliary cancers.

bioRxiv · Oct 20, 2026 · PreprintCancer Biology

Therapy-induced senescent-like cancer cells drive macrophage-mediated immunosuppression in cholangiocarcinoma

Binbin Li, Jingchun Yang, Meina Cai, Shelby K. Yee, Danielle Marie Carlson, Rory L. Smoot, Darren J. Baker, Sumera Irie Ilyas

This study identifies therapy-induced senescent-like cancer cells as drivers of immunosuppression in cholangiocarcinoma by promoting macrophage-mediated suppression of CD8+ T cells.

bioRxiv · Jun 25, 2026 · PreprintCancer Biology

Multiomics-driven discovery of predictive biomarkers and strategies to overcome resistance to SFK-YAP inhibition in cholangiocarcinoma

Hendrien Kuipers, Danielle Marie Carlson, Erik Jessen, Aushinie M. Abeynayake, Jack W. Sample, Dong‐Gi Mun, Jennifer L. Tomlinson, Amro M. Abdelrahman, Nathan W. Werneburg, Binbin Li, Enis H. Ozmert, Caitlin B. Conboy, Mitesh J. Borad, Mark Joseph Truty, Akhilesh Pandey, , Rory L. Smoot

This study identifies biomarkers and resistance mechanisms to SFK-YAP inhibition in cholangiocarcinoma using multiomic profiling and shows synergy with chemotherapy.

bioRxiv · Jan 23, 2026 · PreprintCancer Biology