Darren J. Baker

SEngEAR is a web platform for annotating senescent cells, visualizing communication networks, and comparing senescence signatures across datasets and contexts.

This study identifies therapy-induced senescent-like cancer cells as drivers of immunosuppression in cholangiocarcinoma by promoting macrophage-mediated suppression of CD8+ T cells.

This study uses unbiased cell culture selections to identify DNA aptamers specific to senescent cells, demonstrating their utility as reagents for detecting senescent cells in vitro and in tissues.