Yuan Yuan

Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing

This study shows that Nova proteins, through activity-dependent alternative splicing, are essential for the maturation and connectivity of somatostatin interneurons.

Whole-genome deep learning analysis reveals causal role of noncoding mutations in autism

The paper uses deep learning to analyze whole-genome data from ASD families, showing noncoding mutations significantly impact transcriptional and post-transcriptional regulation and contribute to autism.

Cell type-specific CLIP reveals that NOVA regulates cytoskeleton interactions in motoneurons

The paper develops a method to study cell-type specific RNA regulation in motoneurons and finds NOVA regulates cytoskeleton interactions by promoting a specific isoform of Septin 8.

Differential 3’ Processing of Specific Transcripts Expands Regulatory and Protein Diversity Across Neuronal Cell Types

The paper identifies differences in alternative polyadenylation (APA) between mouse cerebellar neuron types and shows how APA affects gene regulation and function.

Neuron-specific cTag-CLIP reveals cell-specific diversity of functional RNA regulation in the brain

The paper uses NOVA2 cTag-CLIP to study RNA regulation in specific neurons, revealing cell-type differences in RBP actions and their impact on RNA diversity and function.