William C. Nelson

This study identifies extensive proteomic changes in Mycobacterium abscessus under carbon starvation, highlighting the role of the DosRS system in non-replicating persistence.

The paper examines GI activity in a microbial consortium under stress, finding increased excision and expression compared to monocultures, and highlights the importance of community context in GI dynamics.

This study identifies β-lactam targets in Mycobacterium abscessus using chemoproteomics, revealing 17 conserved targets and demonstrating imipenem's superior inhibition over cefoxitin.

This study improves virus visualization in soil using a simple spin filtration method combined with cryo-electron microscopy, revealing previously unseen morphotypes.

The paper introduces an extension to the Snekmer tool that uses kmer libraries to annotate protein sequences with functional annotations, showing improved sensitivity over HMMs in metagenomic datasets.

The paper compares a reduced-genome Rhodopseudomonas strain to others, finding it retains core metabolic versatility but lacks genes for high-affinity transport and biodegradation.

The paper investigates how soil moisture and structure affect microbial phenotypes in a simplified soil analog system, revealing key roles of chitin-degrading bacteria and stress responses in carbon use efficiency.

This study identifies non-opioid receptor proteins that interact with fentanyl across multiple species and tissues using photoaffinity probes and molecular docking.

The paper develops an ANN-based reduced-order model to accelerate FBA integration with RTMs, enabling efficient simulation of microbial metabolic switching in Shewanella oneidensis.

This paper introduces a new biogeochemical modeling approach that explicitly represents organic matter thermodynamics to improve predictions of microbial degradation processes and their environmental impacts.

The paper compares multi-omics data to show that metabolome biochemistry, not microbiome composition or gene expression, correlates with elevated biogeochemical function in hyporheic zones.