The murine lung microbiome is dysbalanced by the human pathogenic fungus Aspergillus fumigatus resulting in enrichment of anaerobic bacteria
Liubov Nikitashina, Xiuqiang Chen, Lukáš Radosa, K. Li, Maria Straßburger, Bastian Seelbinder, Wibke Böhnke, Sarah Vielreicher, Sándor Nietzsche, Thorsten Heinekamp, Ilse Denise Jacobsen, Gianni Panagiotou, Axel A. Brakhage
This study shows that Aspergillus fumigatus infection in immunosuppressed mice disrupts lung microbiome balance, increasing anaerobic bacteria like Ligilactobacillus murinus, which can be internalized by epithelial cells.
Cell Reports · Mar 1, 2025Peer-reviewedMicrobiology