Author

Natalie A. Lamb

University at Buffalo, State University of New YorkORCID 0000-0002-2774-9586Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:yeast· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Jennifer A. SurteesiD· 4 shared Jonathan BardiD· 2 shared Samantha PhelpsiD· 2 shared Anja‐Katrin BielinskyiD· 1 shared Charanya KumariD· 1 shared Grant W. BrowniD· 1 shared Gregory M. WilliamsiD· 1 shared Jordan T. BeckeriD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersGenetics

Jennifer A. SurteesORCID

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4 papers

Recent·Most cited

Mismatch repair MLH complexes make distinct contributions to post-replicative mismatch repair versus trinucleotide repeat expansions

K. Casazza, Gregory M. Williams, Lauren Johengen, Maxwell Keller, Luke D. Hess, Samantha Phelps, Natalie A. Lamb, Jennifer A. Surtees

This study defines the hierarchy of MLH complex functions in Msh2-Msh3-mediated mismatch repair and trinucleotide repeat expansions in yeast.

bioRxiv · Jan 23, 2026 · PreprintGenetics

Msh2-Msh3 interferes with DNA metabolism in vivo

Melisa Medina‐Rivera, Samantha Phelps, Madhumita Sridharan, Jordan T. Becker, Natalie A. Lamb, Charanya Kumar, Mark D. Sutton, Anja‐Katrin Bielinsky, Lata Balakrishnan, Jennifer A. Surtees

This study shows that elevated Msh2-Msh3 levels interfere with DNA replication and long-patch base excision repair in vivo, contributing to genomic instability.

bioRxiv · Sep 6, 2022 · PreprintGenetics

Complex Mutation Profiles in Mismatch Repair and Ribonucleotide Reductase Mutations Reveal Novel Repair Substrate Specificity of MutS Homolog (MSH) Complexes

Natalie A. Lamb, Jonathan Bard, Raphaël Loll‐Krippleber, Grant W. Brown, Jennifer A. Surtees

The paper identifies mutation signatures associated with MMR pathway defects by combining rnr1 and msh mutations, revealing novel repair substrate specificities of Msh2-Msh3 and Msh2-Msh6 complexes.

Genetics · Jun 10, 2022Peer-reviewedGenetics

A targeted next generation sequencing approach to develop robust, genotype-specific mutation profiles and uncover novel variants in Saccharomyces cerevisiae

Natalie A. Lamb, Jonathan Bard, Michael Joseph Buck, Jennifer A. Surtees

The paper develops a targeted sequencing approach to analyze mutation profiles in yeast and identifies genotype-specific variants influenced by dNTP pool changes.

bioRxiv · Jun 25, 2020 · PreprintGenetics