Jennifer A. Surtees

This study defines the hierarchy of MLH complex functions in Msh2-Msh3-mediated mismatch repair and trinucleotide repeat expansions in yeast.

The paper shows that DNA-binding activity alone of Msh2-Msh3 is insufficient to promote trinucleotide repeat expansions in yeast.

This study shows that elevated Msh2-Msh3 levels interfere with DNA replication and long-patch base excision repair in vivo, contributing to genomic instability.

The paper identifies mutation signatures associated with MMR pathway defects by combining rnr1 and msh mutations, revealing novel repair substrate specificities of Msh2-Msh3 and Msh2-Msh6 complexes.

The paper develops a targeted sequencing approach to analyze mutation profiles in yeast and identifies genotype-specific variants influenced by dNTP pool changes.

The paper identifies mlh3 alleles with distinct separation of function phenotypes in meiosis and DNA mismatch repair, revealing the role of protein-protein interactions in regulating Mlh1-Mlh3 activity.