Author

Trine Line Hauge Okholm

Aarhus UniversityORCID 0000-0002-2779-4029Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Andreas Bjerregaard KamstrupiD· 2 shared Christian Kroun DamgaardiD· 2 shared Jakob Skou PederseniD· 2 shared Jørgen KjemsiD· 2 shared Lars DyrskjøtiD· 2 shared Lasse S. KristenseniD· 2 shared Morten Muhlig NielseniD· 2 shared Samuel S. ParkiD· 2 shared

Activity by Year

2019-2024 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Andreas Bjerregaard KamstrupORCID

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3 papers

Recent·Most cited

circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA

Trine Line Hauge Okholm, Andreas Bjerregaard Kamstrup, Morten Muhlig Nielsen, Anne Kruse Hollensen, Mette Laugesen Graversgaard, Matilde Helbo Sørensen, Lasse S. Kristensen, Søren Vang, Samuel S. Park, Eugene Yeo, Lars Dyrskjøt, Jørgen Kjems, Jakob Skou Pedersen, Christian Kroun Damgaard

This paper identifies circHIPK3 as a competing endogenous RNA that sequesters IGF2BP2 to regulate target mRNAs, including STAT3, and shows its correlation with bladder cancer survival.

eLife · Jan 10, 2024Peer-reviewedMolecular Biology

Transcriptome-wide profiles of circular RNA and RNA binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression

Trine Line Hauge Okholm, Shashank Sathe, Samuel S. Park, Andreas Bjerregaard Kamstrup, Asta Mannstaedt Rasmussen, Archana Shankar, Zong Ming Chua, Niels Fristrup, Morten Muhlig Nielsen, Søren Vang, Lars Dyrskjøt, Stefan Aigner, Christian Kroun Damgaard, Gene Wei-Ming Yeo, Jakob Skou Pedersen

The paper identifies circRNA-RBP interactions in cancer, showing their role in circRNA biogenesis and cancer gene expression, with implications for bladder cancer prognosis.

Genome Medicine · Dec 1, 2020Peer-reviewedGenomics

High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome

Liviu-Ionut Moldovan, Thomas B. Hansen, Morten Trillingsgaard Venø, Trine Line Hauge Okholm, Thomas Levin Andersen, Henrik Hager, Lars Iversen, Jørgen Kjems, Claus Johansen, Lasse S. Kristensen

This study uses RNA-seq to compare circRNA expression in lesional and non-lesional psoriasis skin, finding reduced circRNA abundance without clear links to miRNA binding site changes.

BMC Medical Genomics · Nov 27, 2019Peer-reviewedMolecular Biology